Light-activated DNA nanomachinery

DNA is an ideal material for building nanomachinery: it is responsive to stimuli, biocompatible, and can be programmed to assemble into structures of specific sizes and shapes. For example, we can twist and turn one long DNA strand into an arbitrary geometry by ‘stapling’ it with shorter DNA strands through the method of DNA origami. This process creates a nanoparticle with absolute spatial programmability – we can place and orientate any DNA-appended molecule with nanometer precision. These DNA assemblies can then transform by adding stimuli, programming systems to reconfigure, move and actuate like nanorobots. Controlling how long these tasks take requires control over reaction kinetics. We should be able to modulate the speed at which machines transform – slow them down, speed them up, and stop/start them at will – to gain control over the motion of DNA robots at the nanoscale.

In this project you will build synthetic DNA nanomachinery that responds to light and modulates its operation using chemical inputs. These machine parts will transform under irradiation, organizing a biochemical engine that propels DNA nanobots with precision in time and space. You will develop photo-actuated, bio-orthogonal nanomachinery for use in molecular delivery, sensing, and robotics applications. You’ll learn a range of chemical synthesis, self-assembly and microscopy techniques, converging on the fields of supramolecular chemistry, nanotechnology and bioengineering. The project is based on work recently published in Angewandte Chemie and JACS.

Check out our group websites: rizzutogroup.org & bevesgroup.wordpress.com

Applying

Domestic or international students graduated or expecting to graduate with degrees in Chemistry, Biotechnology, Nanoscience or related disciplines are encouraged to apply.

If you meet the UNSW HDR admission requirements, please send an email directly to Dr Felix Rizzuto ([email protected]) with the following information:

Email subject: Prospective PhD for DNA nanobots

Please provide:

–  Your background, experience, and research interests.

–  When you expect to be able to start your PhD if successful.

– A copy of your CV, along with undergraduate and any post-graduate academic transcripts.

– The names and contact information for 2 references.

We apologise that due to the large number of applications typically received, it is not possible to respond to all applicants.