University of Oxford
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Epigenetic and epitranscriptomic changes constitute pivotal factors driving the development and progression of various human cancers, including leukemia. Recent advancements in cancer research underscore the significance of these alterations in shaping complex regulatory networks, not only contributing to the initiation and progression of leukemia but also developing resistance to therapy.
In 2004, our laboratory identified the first histone demethylase, LSD1, whose role was later revealed to be crucial in the initiation and development of several cancers, including leukemia. More recently, our group has unveiled novel RNA modifying enzymes with potential roles in leukemia, presenting exciting opportunities for therapeutic targeting. This D.Phil project aims to unravel the intricacies of epigenetic and epitranscriptomic changes in leukemia, identifying novel therapeutic targets to advance therapy for leukemia patients.
The collaborative environment in our lab provides a rich learning experience, enhancing skills in state-of-the-art technologies. This includes techniques for the analysis of gene regulation (ATAC-seq, ChIP-seq, chromosome-conformation- capture, RNA-seq), advanced molecular biology, genome editing, and computational biology. Trainees participate in weekly internal seminars and monthly external seminars within our Institute, which keep students abreast of recent advancements in cancer research and related fields and provide opportunities for enhancing presentation skills.
Funding Notes
Ludwig studentships provide 4 years funding for a tax-free stipend, currently £21,000 pa and university fees at home and international rates.
Only applications made by the University of Oxford application system for a DPhil in Clinical Medicine will be considered. You may apply for a maximum of two Ludwig projects. Under proposed field and title of research project please enter the project titles in the order of preference. You do not need to provide a research proposal but must include a personal statement.
Please ensure referees are willing to write and submit your reference by the deadline.
Enquiries
Alexandra Royer – [email protected] – application related enquiries
Applications
https://www.ox.ac.uk/admissions/graduate/courses/dphil-clinical-medicine
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