Developing Therapeutic Strategies for Targeting High-Risk Neuroblastoma

This fully funded PhD research, supported by the Faculty of Health, Innovation, Technology and Science, aims to develop a novel therapeutic strategy for high-risk neuroblastoma (HR-NB) using microRNA-based interventions. Neuroblastoma is one of the most common childhood cancers, and despite advances in treatment, the five-year survival rate for HR-NB remains below 50%. Hypoxia plays a critical role in tumour progression and metastasis, with recent research identifying specific microRNAs as key regulators of these processes.

This project will take a multidisciplinary approach, integrating synthetic chemistry, molecular biology and cancer research.

The successful candidate will benefit from an interdisciplinary supervisory team with expertise in molecular oncology, organic chemistry and biochemistry, gaining hands-on experience with cutting-edge research techniques.

Candidate Requirements

We are seeking a highly motivated researcher with:

•             A minimum of a 2.1 undergraduate degree in a relevant discipline. An MSc is preferable.

•             A strong background in cancer biology and molecular cell biology (or biochemistry).

•             Experience in writing research findings to publication standard.

•             Critical thinking and strong organisational skills.

•             The ability to conduct independent research and collaborate across disciplines.

Additional Requirements

·        The candidate must be willing to travel within the UK and internationally to meet project partners, present findings at conferences or participate in public engagement workshops.

·        The successful applicant must be able to start in June 2025 (later start dates cannot be considered).

The Faculty of Science and its three Schools: Biological & Environmental Sciences, Pharmacy & Biomolecular Sciences, and Sports & Exercise Science, have dedicated Diversity and Inclusion (DI) Groups. The individual School Diversity & Inclusion Coordinators and the Faculty Associate Dean for Diversity & Inclusion lead collective action to promote and embed a culture of equality, diversity and inclusivity. All Schools are awarded the Athena SWAN Bronze in recognition of their respective equality initiatives and action plans. Also, Schools have proactive diversity and inclusion groups that are aimed to support staff and students by addressing the inclusivity requirements that are unique to each School, in alignment with the LJMU Diversity & Inclusion policies. Applicants are invited to visit the Faculty of Science https://www.ljmu.ac.uk/about-us/faculties/faculty-of-science and follow the link to each School.