Antigenic Evolution of Neuraminidase in H5Nx Clade 2.3.4.4b Avian Influenza Viruses and its Impact on Viral Fitness in Avian and Mammalian Species

This studentship is open to science graduates with, or who anticipate obtaining, at least a 2:1 or equivalent in a relevant biological subject in an undergraduate degree, or with a Masters degree – subject to university regulations. Other first degrees, e.g. veterinary science, will be considered. You should be looking for a challenging, interdisciplinary research training environment and have an active interest in the control of infectious diseases.

Students without English as a first language must provide evidence that they meet the English language requirement, e.g. with an average IELTS score of 7.0, with no lower than 7.0 in listening/reading and no lower than 6.5 in speaking/writing.

This project tackles the global threat of highly pathogenic avian influenza (HPAI) H5Nx viruses, which continue to pose significant risks to domestic and wild birds while raising serious pandemic concerns due to increasing spillover into mammals. The dominant H5Nx clade 2.3.4.4b has undergone multiple genetic changes in the haemagglutinin (HA) and neuraminidase (NA) along with the genetic reassortment with different NA subtypes complicating control efforts.

The research focuses on unravelling the role of molecular changes in the HA and NA glycoproteins on viral evolution, antigenic diversity, fitness and adaptation across avian and mammalian species. Compared to the hemagglutinin (HA) glycoprotein, NA evolves more slowly but plays a critical role in the viral lifecycle, making it a promising target for next-generation vaccines. By integrating advanced techniques in molecular virology, immunology, vaccinology, bioinformatics, and modelling, the project aims to:

·        Identify molecular factors of NA driving viral evolution and adaptation.

·        Develop improved NA-based vaccines that offer longer-lasting and more effective protection.

This research will pave the way for innovative strategies to control influenza viruses, safeguarding both animal and human health.

The student will be based primarily at The Pirbright Institute and registered with Imperial College London. The student will visit the university to meet with their supervisors and undertake training or complete specific project tasks as required. Highly subsidised Pirbright Institute student housing will be offered. A full range of research and transferrable skills training will be made available to the student as appropriate.

TO APPLY: Full details of how to apply please visit our website: How to apply nearmejobs.eu The Pirbright Institute

For informal enquiries regarding this project please contact the project supervisors. For enquiries regarding eligibility and the application process please email studentship@pirbright.ac.uk