Developing Mechanically Gradient, Electrically Conductive Materials for Soft-Hard Bioelectronic Integration

Project details

Background:

The rapid advancement and increasing application of bioelectronics in the medical and technological sectors spotlight the critical challenge of integrating soft electronic systems with conventional rigid electronics. This integration is essential for the next generation of medical devices, offering seamless functionality and enhanced performance. However, the material incompatibility between flexible, soft bioelectronics and hard, rigid electronic components poses a significant barrier. Addressing this, the proposed project aims to pioneer the development of a novel, electrically conductive material characterised by a gradient in mechanical properties. This innovative material will serve as a bridge, facilitating robust connections between the flexible structures of soft bioelectronic devices and the solid frameworks of traditional electronic systems, thereby ensuring seamless operational synergy in diverse applications.

Objectives:

• To develop a mechanically gradient, electrically conductive material that effectively links soft bioelectronic devices with rigid electronic components.
• To characterise and optimise the electrical and mechanical properties of the developed material for seamless integration in bioelectronic applications.
• Determine biological compatibility in vitro and test with an in-vivo hydrogel electrode. 

Methods:

The project will commence with the synthesis of conductive hydrogels, focusing on achieving the necessary electrical conductivity while maintaining biocompatibility and flexibility. Subsequent efforts will involve developing materials with a mechanical gradient from soft to hard through controlled polymer crosslinking, using techniques such as additive manufacturing and electrospinning tailored for bioelectronic interfaces. Comprehensive testing will assess these materials’ electrical and mechanical properties and their interface compatibility to ensure seamless integration with both soft and hard conductive materials. Finally, biological compatibility and effectiveness will be evaluated through standard in vitro assays and in vivo testing using a hydrogel-based neuroelectrode in a rat model, focusing on the material’s performance as a conductive bridge in bioelectronic applications.

Expected Outcomes:

• Development of a novel material that provides a functional bridge between soft bioelectronic devices and rigid electronics.
• A comprehensive understanding of the material’s electrical and mechanical properties, ensuring its suitability for bioelectronic applications.
• Enhanced integration strategies for bioelectronic devices, paving the way for advanced medical technologies and applications.

Impact:

The successful completion of this project is expected to significantly advance the field of bioelectronics by providing a viable solution to one of its most pressing challenges: the integration of soft and hard electronic components. The development of a mechanical gradient, electrically conductive material will facilitate the creation of more sophisticated and functional bioelectronic devices and open new avenues for research and application in medical technologies and beyond.

Entry Requirements:

Candidates must have a first or upper second class honours degree or significant research experience.

How to apply:

Please complete a University Postgraduate Research Application form available here: www.shef.ac.uk/postgraduate/research/apply

Please clearly state the prospective main supervisor in the respective box and select (School of Clinical Dentistry) as the department.