Dissecting calcium signalling in Marchantia polymorpha (MILLER_U25DTP)

Primary Supervisor – Dr Ben Miller 

Plants need to respond to the environment in order to adapt and grow. Plants often modify the concentration of calcium ions in their cells in response to different environmental stimuli and stresses [1]. These changes in cellular calcium concentration trigger many downstream responses, including re-programming of gene expression. Calcium signalling pathways are therefore essential for plants to respond and adapt to environmental stimuli and stresses.  

Flowering plants, such as the model plant Arabidopsis thaliana, have extensive networks of proteins associated with calcium signalling pathways, and traditional genetic studies have identified mutants in components of these pathways. However, genetic redundancy is often observed and this has hindered further study of these signalling pathways. Recent genomic analyses have revealed that the gene families encoding components of calcium signalling pathways are considerably smaller in other model plant species, including in the liverwort Marchantia polymorpha [3]. The study of these pathways in M. polymorpha will therefore offer unique insights and understandings into calcium signalling pathways in plants, and may identify new potential targets that could be manipulated to improve stress tolerance in crop species.  

This PhD project will undertake a multi-disciplinary approach combining molecular genetics, computational analyses and biochemistry to dissect calcium signalling and decoding mechanisms in the liverwort Marchantia polymorpha. 

The Norwich Research Park Biosciences Doctoral Training Programme (NRPDTP) is offering fully funded studentships for October 2025 entry. The programme offers postgraduates the opportunity to undertake a 4-year PhD research project whilst enhancing professional development and research skills through a comprehensive training programme. You will join a vibrant community of world-leading researchers. All NRPDTP CASE students undertake a three to 18-month placement with the non-academic partner during their study. The placement offers experience designed to enhance professional development. Full support and advice will be provided by our Professional Internship team. Students with, or expecting to attain, at least an upper second-class honours degree, or equivalent, are invited to apply. 

This project has been shortlisted for funding by the NRPDTP. Shortlisted applicants will be interviewed on 28, 29 or 30 January 2025.  

Visit our website for further information on eligibility and how to apply: https://biodtp.norwichresearchpark.ac.uk/ 

Our partners value diverse and inclusive work environments that are positive and supportive. Students are selected for admission without regard to gender, marital or civil partnership status, disability, race, nationality, ethnic origin, religion or belief, sexual orientation, age or social background. 

Entry requirements

At least UK equivalence Bachelors (Honours) 2:1 or UK equivalence Master’s degree. English Language requirement (Faculty of Science equivalent: IELTS 6.5 overall, 6 in each category). 

Mode of study

Full time

Start date

1 October 2025