Effects of Hypomagnetic Field Exposure on the Human Gut Microbiome and Its Implications for Human Health

We are looking for a PhD student to develop a 3D in vitro model of human gut to model human gut-microbiome interactions. Environmental factors such as microgravity, radiation and hypomagnetic fields (HMF) may alter microbial function and lead to microbiome dysbiosis during spaceflights. However, the extent of these alterations and the exact mechanisms are yet to be determined.

In this project, the core human microbiome will be constructed using synthetic microbial communities and analysed to characterise phenotypic and genotypic modifications before and after exposure to HMF. Additionally, a human 3D gut model will be developed using intestinal epithelial cell-lines. The model will be co-cultured with the constructed microbiome and immune cells to examine host-gut microbiome interactions under HMF condition and determine whether HMF can lead to gut microbiome dysbiosis and inflammation. This project will enhance our understanding of human gut microbiome behaviour in space exploration, aiming to support a healthy microbiome by preventing dysbiosis or developing therapeutic alternatives.

The successful candidate will gain expertise in developing 3D in vitro models, constructing synthetic microbial communities, whole genome sequencing, metabolomics, and immunological techniques. They will also have the opportunity to present at national and international conferences.

These PhD opportunities will include comprehensive personal and professional development training and a mentoring programme from the University of Westminster Graduate School. The researchers will join a School firmly committed to decolonising and diversifying policies, practices, and cultures within, and beyond, Higher Education. 

Entry requirements and how to apply

Candidates should have a minimum classification of 2.1 in their bachelor’s degree or equivalent and preferably a Masters degree. Applicants whose secondary level education has not been conducted in the medium of English should also demonstrate evidence of appropriate English language proficiency normally defined as IELTS: 6.5 (overall score with not less than 6.0 in any of the individual elements).

You can read more about what should be in a PhD research proposal here:

https://www.westminster.ac.uk/study/postgraduate/research-degrees/entry-requirements/how-to-write-your-research-proposal

You can read more about our entry requirements here:

http://westminster.ac.uk/study/postgraduate/research-degrees/entry-requirements

Applications should be submitted by Friday 16^th May 2025. Interviews will take place in June.

It is essential you include the code of the project you are applying for in your personal statement i.e. “SLS SF1”.

Also include the title of the specific project you wish to apply for in your application.