Epigenetic profiling of cereal fungal invaders. (SAUNDERS_J24DTP1)

Wheat blast and rusts are fungal diseases that severely damage cereal production worldwide. During infection, these fungi secrete proteins into wheat plants to reprogramme host plant circuitry, supporting their own growth and development. A subset of effectors, termed avirulence factors (Avr), can be recognised by corresponding host resistance (R) proteins, rendering the pathogen avirulent and halting its growth. However, host recognition creates strong evolutionary pressure on pathogen Avr effectors, favouring their modification to evade immune responses. This leads to frequent emergence of new virulent pathogen races, compromising R-gene mediated resistance and limiting longevity of R genes. The mechanisms leading to changes in pathogen Avr effectors are diverse. Yet, one potential, understudied strategy for pathogens to avoid recognition is to conceal Avr proteins by preventing their synthesis – a process regulated by epigenetic switching. 

The student will use an array of approaches to determine the contribution of epigenetic switching of Avr factors in the evolution of new wheat blast and rust strains. This will include conducting genome-wide analysis of epigenetic marks in blast and rust strains, whilst determining the contribution of specific epigenetic regulators to fungal virulence and development in the genetically tractable wheat blast fungus. This project provides a unique opportunity to join two leading multidisciplinary research teams at the John Innes Centre and The Sainsbury Laboratory, which are centers of excellence in plant science and plant-microbe interactions. 

The Norwich Research Park (NRP) Biosciences Doctoral Training Programme (DTP) is offering fully-funded studentships for October 2024 entry. The programme offers postgraduates the opportunity to undertake a 4-year PhD research project whilst enhancing professional development and research skills through a comprehensive training programme. You will join a vibrant community of world-leading researchers. All NRPDTP students undertake a three-month professional internship placement (PIPS) during their study. The placement offers exciting and invaluable work experience designed to enhance professional development. Full support and advice will be provided by our Professional Internship team. Students with, or expecting to attain, at least an upper second class honours degree, or equivalent, are invited to apply. 

This project has been shortlisted for funding by the NRPDTP. Shortlisted applicants will potentially be interviewed on either the 14 or 15 August 2024.

Visit our website for further information on eligibility and how to apply: https://biodtp.norwichresearchpark.ac.uk/ 

Our partners value diverse and inclusive work environments that are positive and supportive. Students are selected for admission without regard to gender, marital or civil partnership status, disability, race, nationality, ethnic origin, religion or belief, sexual orientation, age or social background.