The University of Manchester
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Peripheral nerve injuries are common, with approximately 9000 cases occurring each year in the UK in a predominantly young and working population. Despite microsurgical nerve repair techniques, normal restoration of function is unattainable, which results in impaired sensation, reduced motor function and frequent pain and cold intolerance. Such injuries have a profound and permanent impact on the patient and their ability to perform daily living activities with less than 60% returning to work.1
The current method of repairing a large gap between nerve endings is to graft nerves taken from another area of the patient (autograft). This results in a further surgical procedure and morbidity at the harvesting site. In addition, there is limited donor nerve availability. This state of affair has prompted researchers to focus on the design and use of bio-engineered nerve conduits (tubes), an artificial means of guiding nerve regeneration. However, to date, commercially available conduits have not been able to match the results of the current clinical state of the art technique (autograft). This is likely due to the nerve conduits in current use being empty tubes and failing to re-create the 3-dimentional environment required for optimal nerve regeneration.2
The challenge we will tackle through this project is the design of a fully defined synthetic 3D-scaffold that promotes nerve regeneration. The project will combine two novel technologies developed in Manchester in Prof Saiani & Miller and Dr Reid laboratories. The potential of novel peptide-based hydrogel that have been demonstrated to permit cells, including stem cells, to thrive to be used to deliver adipose derived stem cells and within a novel micro-grooved PCL conduit. This conduit has already been the subject of a phase 1 clinical trial in small nerve gaps but will require specialised cell support to address the clinical challenge of long nerve gaps.
Entry requirements
Candidates are expected to hold (or be about to obtain) a minimum UK Upper First or 2:1 (or equivalent) in a related area / subject.
How to apply
For information on how to apply for this project, please visit the Faculty of Biology, Medicine and Health Doctoral Academy website (https://www.bmh.manchester.ac.uk/study/research/apply/).
Interested candidates must first make contact with the Primary Supervisor prior to submitting a formal application, to discuss their interest and suitability for the project.
On the online application form select PhD Biochemistry (this is for application purposes only).
Equality, Diversity and Inclusion
Equality, diversity and inclusion is fundamental to the success of The University of Manchester, and is at the heart of all of our activities. The full equality, diversity and inclusion statement can be found on the website https://www.bmh.manchester.ac.uk/study/research/apply/equality-diversity-inclusion/
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