Immune Hedgehog signalling dynamics in health and disease

Overview

Dr Maike de la Roche wishes to recruit a student to work on the project entitled: “Immune Hedgehog signalling dynamics in health and disease”.

For further information about the research group, including their most recent publications, please visit our website at https://www.cruk.cam.ac.uk/research-groups/de-la-roche-group/

This is a unique opportunity for PhD study in the world-leading Cancer Research UK Cambridge Institute (CRUK CI), to start a research career in an environment committed to training outstanding cancer research scientists of the future.

The Institute’s particular strengths are in genomics, computational biology and imaging; and significant research effort is currently devoted to cancers arising in the breast, pancreas, brain, and colon. Our Core Facilities provide researchers with access to state-of-the-art equipment, in-house expertise and training. Scientists at CRUK CI aim to understand the fundamental biology of cancer and translate these findings into the clinic to benefit patients.

There are around 100 postgraduate students at the Cambridge Institute, who play a vital and pivotal role in its continuing success. We are committed to providing an inclusive and supportive working environment that fosters intellectual curiosity and scientific excellence.

If you are interested in finding out more about our groundbreaking scientific research, please visit our website at https://www.cruk.cam.ac.uk/

Project details

While we and others have discovered pivotal roles of the Hedgehog pathway in immune cells, Hedgehog signalling dynamics and interaction partners within the cells of the immune system remain elusive. The project aims to shed light on this by using chromobody technology, bespoke mouse models and proximity labelling techniques.

The student will work with murine and human immune cells and the fundamental mechanistic insight gained may inform novel therapeutic entry points into cancer, infection and autoimmunity.

Preferred skills/knowledge

Immune system, immune assays, molecular biology, flow cytometry

Eligibility

We welcome applications from both UK and overseas students.

Applications are invited from recent graduates or final-year undergraduates who hold or expect to gain a First/Upper Second Class degree (or equivalent) in a relevant subject from any recognised university worldwide.

Applicants with relevant research experience, gained through Master¿s study or while working in a laboratory, are strongly encouraged to apply.

How to apply

Please apply via the University Applicant Portal. For further information about the course and to access the Applicant Portal, visit:

https://www.postgraduate.study.cam.ac.uk/courses/directory/cvcrpdmsc You should select to commence study in Michaelmas Term 2025 (October 2025).

Additional information

To complete your online application, you will need to answer/provide the following:

– Choice of project and supervisor

Please ensure that you name the project (with reference code) and supervisor, where indicated. You are permitted to apply for up to three projects.

– Course-specific questions

• You will be asked to give details of your Research Experience (up to 2,500 characters).
• Your Statement of Interest (up to 2,500 characters) should explain why you wish to be considered for the studentship and what qualities and experience you will bring to the role.

– Supporting documents

Applicants will be asked to provide:

• Academic transcripts.
• Evidence of competence in English (if appropriate).
• Details of two academic referees.
• CV/resume.

Deadline

The closing date for applications is 31st October 2024 with interviews expected to take place in January 2025.

The University of Cambridge actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University of Cambridge has a responsibility to ensure that all employees are eligible to live and work in the UK.