Investigating the neuroprotective efficacy and downstream receptor mechanisms of the natural isothiocyanate Sulforaphane in an Oxygen-Glucose deprivation model of transient cerebral ischaemia with reperfusion

Stroke impacts approximately 15 million people globally and is the leading cause of death in upper income countries as well as the third leading cause of death and leading cause of morbidity worldwide. Treatment for stroke, once it has occurred, has been limited with only one therapeutic agent available clinically that can treat 1-3% of stroke victims. Sulforaphane (SFN), is a naturally available isothiocyanate found in many cruciferous vegetables such as broccoli and cabbage and appears to have potential anti-inflammatory, antioxidant and pro-resolving properties. This project will therefore investigate the potential neuroprotective efficacy and downstream cellular and molecular pathways of SFN in a human cell-culture model of stroke known as Oxygen-Glucose Deprivation. 

These PhD opportunities will include comprehensive personal and professional development training and a mentoring programme from the University of Westminster Graduate School. The researchers will join a School firmly committed to decolonising and diversifying policies, practices, and cultures within, and beyond, Higher Education. 

Entry requirements and how to apply

Candidates should have a minimum classification of 2.1 in their bachelor’s degree or equivalent and preferably a Masters degree. Applicants whose secondary level education has not been conducted in the medium of English should also demonstrate evidence of appropriate English language proficiency normally defined as IELTS: 6.5 (overall score with not less than 6.0 in any of the individual elements).

You can read more about what should be in a PhD research proposal here:

https://www.westminster.ac.uk/study/postgraduate/research-degrees/entry-requirements/how-to-write-your-research-proposal

You can read more about our entry requirements here:

http://westminster.ac.uk/study/postgraduate/research-degrees/entry-requirements

Applications should be submitted by Friday 16^th May 2025. Interviews will take place in June.

It is essential you include the code of the project you are applying for in your personal statement i.e. “SLS SF1”.

Also include the title of the specific project you wish to apply for in your application.