PhD-position at the Department of Clinical Medicine

13th August 2023
Languages
English

• English
• Norsk Nynorsk

English
PhD-position at the Department of Clinical Medicine
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PhD-position

At the Faculty of Medicine, Department of  Clinical Medicine, Centre for Cancer Biomarkers (CCBIO), a full-time PhD-position is available for a period of four (4) years or max 4 months after completed the PhD-degree, if this is achieved within a shorter time than four years. The positions include 25 % required duties such as teaching, exam work or supervision, depending on the demands at the department.

The position is part of the project “EvoMaps – Understanding Early Breast Cancer Evolution in Space and Time”, funded by the University of Bergen.

About the project/work tasks:

Ductal carcinoma in situ (DCIS) is considered a premalignant lesion. However, only few DCIS lesions have the potential to progress to invasive breast cancer. Since underlying evolutionary processes are largely unknown, the clinical prediction of DCIS progression remains difficult. The PhD project aims to elucidate regulatory mechanisms of early breast cancer evolution and progression in its microenvironmental tissue context. Therefore, the PhD student will apply state-of the art tissue-based analyses in order to identify and describe cellular ecosystems, where interactions between tumor cells and their adjacent microenvironment drive clonal expansion and disease progression during early tumor stages. In the long-term perspective, the study will set the basis to uncover novel therapeutic opportunities as well as clinically relevant treatment stratification models for early breast cancer patients with special focus on radiotherapy.

We are looking for a curious and enthusiastic PhD student, with a great interest in studying the molecular mechanisms of radioresistance in early breast cancer. The PhD project will include the set-up 3D cell cultures from primary early breast cancer tissue samples in order to establish a high throughput screening assay for the identification of molecular mediators of radioresistance. These efforts will be complemented with in vivo radiation experiments using patient-derived mouse-intraductal DCIS models. A central aspect of the doctoral studies will be to learn how to set and discuss the generated data in the broader context of current literature. Additional tasks might include complementary spatial in situ analyses via imaging mass cytometry (Hyperion), in situ sequencing and proximity ligation assay for comprehensive signaling-profiling of the tumor microenvironment in the context of radiotherapy response.

We offer a highly interdisciplinary working environment within the field of translational cancer research. The project is closely embedded within our international collaboration network and will offer opportunities for research stays at our collaborators.

Qualifications and personal qualities:

• The applicant must hold a master`s degree or equivalent in the relevant field (e.g. Biochemistry, Molecular Biology, Biomedicine, Pathology or Bioinformatics)
• Experience with cell culture is required
• Experience with mouse handling and experimental mouse models (preferably cancer models) is required and ideally the candidate should hold a certificate in Laboratory animal sciences
• Basic knowledge in bioinformatics including programming (e.g. R) is required
• Good knowledge in molecular biology techniques including RNA and DNA isolation, PCR, RT-PCR and cloning will be a strong merit
• Knowledge on RNAseq and or ATAC-seq will be a strong merit
• The candidate should be able to work independently and in a structured manner, and have the ability to cooperate with others
• The applicant should be willing to travel e.g. in the context of research stays at international collaboration partners
• The applicant must be fluent in oral and written English, see documentation requirements

Applicant whose education is from another country than Norway, need to also attach a certified translation of the diploma and transcript of grades to English or a Scandinavian language, if the original is not in any of these languages. It is required that the applicant enclose a review from NOKUT whether the education in question (bachelor and master’s degree) is of a scope and level that corresponds to the level of a Norwegian master’s degree. Please see www.nokut.no/en for more information about NOKUT’s general recognition. The review from NOKUT may take some time and the application should be sent to NOKUT as soon as you have decided to apply for the position. If no answer within the application deadline, you must enclose documentation from NOKUT that they have received your application.

See documentation requirements for language qualifications: http://www.uib.no/en/med/115526/english-language-requirements-phd-admission

About the PhD position:

Organized research training (PhD program):
The candidate must take part in the University of Bergen approved PhD programme leading to the degree within a time limit of 3 years. You must have admission to the organized research training (PhD program) at the Faculty in order to qualify for the position.

Application for admission to the PhD programme, including a project plan outline for the training plan must be submitted no later than three months after the date of commencement.

The PhD-position:
PhD-positions are fixed term positions. You cannot be employed in a PhD-position for more than one fixed term period at the same institution or have had similar employment at an institution in the region.

We can offer:

• Exciting development opportunities as part of your role in a strong professional environment
• Salary NOK 540 500 (code 1017, pay grade 55) in the state salary scale. For applicants with at least one year of employment in a position as a General Practitioner or Dentist, salary NOK 557 100 (code 1017, pay grade 57). Medical specialist starts on salary NOK 575 400 (code 1017, pay grade 59)
• Enrolment in the Norwegian Public Service Pension Fund
• Good welfare benefits

Your application must include:

• A brief account of the applicant`s research interests and motivation for applying for the position
• Certified copies of diplomas and transcripts of grades
• Applicant whose education is from another country than Norway, need to also attach a certified translation of the diploma and transcript of grades to English or a Scandinavian language, if the original is not in any of these languages. It is required that the applicant enclose a review from NOKUT whether the education in question (bachelor and master degree) is of a scope and level that corresponds to the level of a Norwegian master’s degree. Please see www.nokut.no/en for more information about NOKUT’s general recognition. This may take some time and we recommend you to apply as soon as you know you will apply for this position. If no answer within the application deadline, please enclose documentation from NOKUT that they have received your application
• Documentation of language skills (English) http://www.uib.no/en/med/115526/english-language-requirements-phd-admission
• Complete list of publications and scientific work you want to be evaluated
• Any publication in your name
• Two references (name and contact information)

General information:

For further information please contact Carina Strell, e-mail: [email protected]

The state labour force shall reflect the diversity of Norwegian society to the greatest extent possible. People with immigrant backgrounds and people with disabilities are encouraged to apply for the position.

The University of Bergen applies the principle of public access to information when recruiting staff for academic positions.

Information about applicants may be made public even if the applicant has asked not to be named on the list of persons who have applied. The applicant must be notified if the request to be omitted is not met.

The successful applicant must comply with the guidelines that apply to the position at all times.

For further information about the recruitment process, click here .

via Unsplash

Life as a PhD candidate at UiB

Marion Claireaux tells about life and work as a PhD candidate at UiB.

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via Unsplash

About UiB

The University of Bergen is a renowned educational and research institution, organised into seven faculties and approximately 54 institutes and academic centres. Campus is located in the centre of Bergen with university areas at Nygårdshøyden, Haukeland, Marineholmen, Møllendalsveien and Årstad. 

There are five departments and eight centres at Faculty of Medicine.

Read More about the facult y and departments .

 

Apply for this job
Deadline

13th August 2023

Employer

University of Bergen

Municipality

Bergen

Scope

Fulltime (1 positions)
Fulltime

(%)

Duration

Fixed Term

Place of service

Det medisinske fakultet, 5021 Bergen

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