Medical College of Wisconsin
The postdoctoral fellow will be an essential collaborator in our newly funded strategically focused research network (SFRN) of the American Heart Association with a focus on Disparities in Cardio-Oncology. MCW is one of four sites nationally. The successful applicant will cross train on two of the three projects of this center grant and have opportunities to interact with other sites of the SFRN. The center consists of a population science project, clinical project, and basic science project. Existing expertise in at least one of the following focus areas is desired: population science and behavioral interventions, human physiology and vascular biolgy, cardiovascular OMICs, data science.
The overall goals of the center are:
1. Quantify physiological and molecular differences in inflammation and endothelial function before and following chemotherapy among non-Hispanic black and African American compared with non-Hispanic white breast cancer patients receiving chemotherapy.
2. Test the feasibility and efficacy of an exercise intervention designed to mitigate the adverse effects of chemotherapy
3. Examine the influence of socio-ecological factors (individual, interpersonal, systemic, environmental) on inflammation, microvascular endothelial function, QoL and response to the exercise intervention.
We aim to implement a rigorous transdisciplinary post-doctoral training program designed to develop future investigative leaders to work at the intersection of cancer, cancer therapy, cardiovascular disease (CVD) and health disparities/health equity. Our program emphasizes the principles of collaboration, innovation, rigor and reproducibility, and appreciation for the social determinants of health, health disparities and cultural humility. Each trainee will gain meaningful knowledge, skills and experience, forming a strong foundation on which to build a career trajectory leading to independence in cardiology/cancer and disparities research. Our curriculum and SFRN project engagement will ensure that each fellow is exposed to the spectrum of investigative approaches including molecular biology and proteomics, physiological assessments, population health, disparities, and community engagement. A highly focused research project will provide an opportunity for the fellow to develop deep expertise in one or two of these areas. Mentoring teams will provide expertise, support, and connections among projects and with other SFRN centers. Our network is committed to bringing together diverse teams and creating an environment of belonging and inclusive excellence. The overarching goal of this center is to define the impact of cancer therapy on the human circulatory system, with a focus on racial disparities. Specifically, we address the role that socioeconomic and environmental factors play in modulating exercise capacity, quality of life, endothelial function, and molecular cardiovascular risk profile among women with non-metastatic breast cancer currently undergoing chemotherapy. A clinical trial will be conducted to determine whether exercise has beneficial effects in reducing vascular toxicity. We aim to capture the molecular and physiological correlates of cancer treatment toxicity in the blood and microcirculation as a potential means of predicting cardiac related effects of treatment. Our focus will be on non-Hispanic black and white populations in Milwaukee and Chicago using geospatial approaches to identify and characterize high stress environments.
KNOWLEDGE, SKILLS, & ABILITIES
*Knowledge of research questions development, scientific approach and methodologies
*Ability to develop and follow research methodology and protocols.
*Basic and advanced data analysis skills
*Scientific writing and presentation skills
*Knowledge of current technological developments/trends in area of expertise
*Ability to read, understand, follow and enforce safety procedures
*Ability to design, organize and coordinate scientific research project
Full time role with expectations for coverage during core business hours and flexibility required as necessary to accommodate business needs.
* PhD or equivalentprior to starting the positionin public health, social sciences, exercise or human physiology, genetics, or related disciplines
* Strong Background in human and/or vascular physiolgy, experience in molecular biolgy related to cytokine signaling, whole genome sequencing, whole genome sequencing.
* Knowledge of biomarkers related to Cancer and Cardiovasscsular disease.
* Previous experience with human subjects research, work in vascular function measurements in vivo or in vitro and/or OMICs, health disparities/health equity, community engagement in racially diverse area (all preferred).
- Outstanding Healthcare Coverage, including but not limited to Health, Vision, and Dental. Along with Flexible Spending options
- 403B Retirement Package
- Competitive Vacation and Paid Holidays offered
- Tuition Reimbursement
- Paid Parental Leave
- On campus Fitness Facility, offering onsite classes.
- Additional discounted rates on items such as: Select cell phone plans, local fitness facilities, Milwaukee recreation and entertainment etc.
For a full list of positions see: www.mcw.edu/careers
For a brief overview of our benefits see: https://www.mcw.edu/departments/human-resources/benefits
Eastern Wisconsin is a vibrant, diverse metropolitan area. MCW is intent on attracting, developing, and retaining a diverse workforce and faculty body that reflects the community we serve. We value diversity of backgrounds, experience, thought, and perspectives to advance excellence in science and medicine. MCW is a welcoming campus community with a strong culture of collaboration, partnership, and engagement with our surrounding community.
MCW as an Equal Opportunity Employer and Commitment to Non-Discrimination
The Medical College of Wisconsin (MCW) is an Equal Opportunity Employer. We are committed to fostering a diverse community of outstanding faculty, staff, and students, as well as ensuring equal educational opportunity, employment, and access to services, programs, and activities, without regard to an individual’s race, color, national origin, religion, age, disability, sex, gender identity/expression, sexual orientation, marital status, pregnancy, predisposing genetic characteristic, or military status. Employees, students, applicants or other members of the MCW community (including but not limited to vendors, visitors, and guests) may not be subjected to harassment that is prohibited by law or treated adversely or retaliated against based upon a protected characteristic.
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