Postdoctoral Research Associate – Chemical Biology & Therapeutics

We are recruiting a postdoc for a project that sits at the interface of chemical and structural biology by investigating dynamic protein ligand interfaces with a view towards ligand discovery.

 

The position is available immediately. 

 

We are looking for highly motivated candidates with curiosity and skills to reveal hidden factors that contribute to protein dynamics, hydration and protein-ligand binding and leverage this information for ligand discovery. This project integrates experimental and computational data and will benefit from computational skills for custom data analysis and automation, and a solid background in structural biology. 

 

The project is housed in the Department of Chemical Biology and Therapeutics at St. Jude Children’s Research Hospital. It builds on strong investments into a world-class infrastructure in structural and chemical biology. You will be embedded into a dynamic lab that has strong expertise in modulating protein conformational ensembles with ligands and temperature (see references below). This is an exciting time to join us and build a career while living in an affordable city. 

 

Essential requirements:
–    PhD in structural biology or related field
–    High proficiency in analysis of structural data
–    Interest in protein dynamics, hydration and ligand discovery 
–    Hands-on experience in molecular biology/ protein biochemistry

 

Optional requirements:
–    Proficiency in coding and data analysis (including Python) will facilitate data processing and analysis

–    Experience in molecular dynamics simulations, free-energy perturbation, Rosetta, computational chemistry

Please direct your questions and application package including a cover letter, current CV, and 3 letters of reference to: Dr. Marcus Fischer (marcus.fischer@stjude.org).

 

Relevant papers include:
• Stachowski and Fischer (2024). FLEXR GUI: a graphical user interface for multi-conformer modeling of proteins. J Appl Cryst 57
• Stachowski and Fischer (2023). FLEXR: automated multi-conformer model building using electron-density map sampling. Acta D 354-367. 
• Stachowski and Fischer (2022). Large-scale ligand perturbations of the protein conformational landscape reveal state-specific interaction hotspots. J Med Chem. 13692-13704
• Stachowski et al. (2022). Water networks repopulate protein-ligand interfaces with temperature. DOI: 10.1002/anie.202112919
• Bradford et al. (2021). Temperature artifacts in protein structures bias ligand-binding predictions. Chemical Science. DOI: 10.1039/D1SC02751D
• Fischer (2021). Macromolecular room temperature crystallography. Q Rev Biophys 54. E1 
• Darby et al. (2019). Water networks can determine the affinity of ligand binding to proteins. JACS 141, 15818-26. 
• Balius et al. (2017). Testing inhomogeneous solvation theory in structure-based ligand discovery. PNAS E6839-46. 
• Fischer et al. (2014). Incorporation of protein flexibility & conformational energy penalties in docking screens to improve ligand discovery. Nature Chemistry 6, 575-83. 

 

More info at:
https://www.stjude.org/fischer
https://scholar.google.com/citations?user=ijs3_vIAAAAJ&hl=en&oi=ao

 

Diversity, Equity and Inclusion

St. Jude Children’s Research Hospital has a diverse, global patient population and workforce, built on the principles of diversity, equity and inclusion. Our founder Danny Thomas envisioned a hospital that would treat children of the world—regardless of race, religion or a family’s ability to pay. Learn more about our history and commitment.

 

Today, we continue the mission to advance cures and means of prevention for pediatric catastrophic diseases through research and treatment. As we accelerate this progress globally, we believe our legacy of diversity, equity and inclusion is foundational to success. With the commitment of leaders at all levels of the organization, we strive to ensure the St. Jude culture, leadership approaches and talent processes are equitable and culturally responsive. View our Diversity, Equity and Inclusion Report to learn about the hospital’s roots in diversity, equity and inclusion, where we are today and our aspirations for an even better future.

 

St. Jude is an Equal Opportunity Employer

 

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