Quantum imaging of bioelectric signalling in colorectal cancer organoids

This project is part of the EPSRC Centre for Doctoral Training in Quantum Technology Engineering at the University of Southampton https://qte.ac.uk/). In addition to the research project outlined below, you will receive substantial training in scientific, technical, and commercial skills.

This project aims to investigate the bioelectric heterogeneity of colorectal cancer, using quantum diamond sensing. We will utilize nitrogen-vacancy centers in diamond to image the spatial distribution of bioelectric fields within colorectal cancer cells from established cell lines. By correlating bioelectric signatures with cell types and ion channel profiles, we aim to advance the field of NV centers in diamond for biological sensing. Imaging will be performed using a custom-built wide-field microscope. Cells responses will be assessed using biological assays, and correlated with spatially resolved bioelectric data using machine learning algorithms. This project will involve a multidisciplinary collaboration between the departments of Electronics and Computer Science, Optoelectronics, and Cancer Sciences at the University of Southampton, as well as the Bioengineering Institute at Instituto Superior Tecnico in Lisbon.

For more information, please contact the lead supervisor: Dr Rosalia Moreddu, [email protected]

Entry Requirements

Undergraduate degree (at least UK 2:1 honours degree, or international equivalent).

Closing date

Applications are accepted throughout the year for a start date in September 2025. Overseas students requiring funding must apply before 31 March 2025.

Funding

Funding on a competitive basis. For UK students, tuition fees and a stipend at the UKRI rate tax-free for 4 years. EU and Horizon Europe students are eligible for scholarships. Overseas students who have secured or are seeking external funding are welcome to apply.

How to apply

Apply online here: Select programme type “Research”, “Faculty of Engineering and Physical Sciences”, next page select “PhD Quantum Tech Eng”. In Section 2 of the application form insert the name of the supervisor.

Applications should include

Applications should include (further details on https://qte.ac.uk/phd-opportunities/ ): Personal statement; Curriculum Vitae; Contacts of two referees; Degree Transcripts/Certificates to date.

We are committed to promoting equality, diversity, and inclusivity and give full consideration to applicants seeking part-time study. The University of Southampton takes personal circumstances into account, has onsite childcare facilities, is committed to sustainability and has been awarded the Platinum EcoAward.