Senior Pharmaceutical Scientist, Peptide/bro5 Discovery Pharmaceutics

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com

Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Pharmaceutical Product R&D

Job Category:

Scientific/Technology

All Job Posting Locations:

Beerse, Antwerp, Belgium

Job Description:

We are searching for the best talent for a Senior Pharmaceutical Scientist Discovery Pharmaceutics to join our Pharmaceutical Product Development & Supply (PPDS), in Beerse, Antwerp, Belgium

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

Purpose: We are growing our capabilities in designing and formulating peptides, protein degraders and other beyond-rule-of 5 molecules. Our Discovery-facing team supports Discovery programs from Hit-to-Lead through the identification and selection of clinical assets. As core member of cross-functional teams, you will closely collaborate with key partners, including chemistry, biology, pharmacokinetics, and pre-clinical safety.

You will be responsible for:

• influence molecular design by providing experimental and intellectual input on their physical properties and how these properties affect formulation options
• influence the drug delivery selection for our Discovery molecules and lead candidate drugs by identifying patient-centric formulations and novel formulation solutions to overcome challenges
• contribution to the selection of drug candidates by inputting pharmaceutics and developability knowledge
• collaboration with Development partners and provide recommendations on aspects such as solid form selection and formulation strategy for toxicological studies and First-in-Human clinical trials
• hands-on and in silico experimentation and data generation.

We are looking for a dynamic and driven individual with a robust background in peptide, protein degrader or other beyond-rule-of-5 molecule physical properties. The successful candidate will have strong interpersonal skills, mental agility and thrive in teams working in a fast-paced environment, and meet the following qualifications.

Qualifications / Requirements:

• Ph.D. degree (2-6 years’ experience), M.S. degree (4-10 years’ experience) or B.S. degree (>8 years’ demonstrated ability) in Pharmaceutical Sciences, Industrial Pharmacy, Biochemical Engineering, Medicinal Chemistry, Chemical Engineering, Biological or Physical Sciences, or a closely related field.
• Formulation design or strong knowledge of physical properties of peptides, protein degrader or other beyond rule of 5 molecules.
• Sustained experience in implementing ideas into practical solutions.
• Excellent oral and written communication skills.
• Ability to conduct laboratory experiments.
• Detailed understanding of physical and pharmaceutical chemistry principals.
• Independent thinking and the ability to effectively collaborate.

Preferred experience:

• Novel drug delivery, data analytics or pharmacokinetics.
• Design and development of small molecule formulation concepts for preclinical studies via various routes of administration.
• Characterization techniques such as DVS, DSC, TGA, PXRD, UPLC, mass spectrometry etc., and interpretation of solid-state characterization, chemical and physical stability and solubility data.
• Familiarity with pre-formulation activities and physicochemical characterization of Active Pharmaceutical Ingredients (APIs).
• Track record of scientific contributions including peer reviewed publications, patents and/or presentations.

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