Special Postdoctoral Fellow in Cell Surface Receptors and Transmembrane Signaling

Join the Lab of Tim Springer
Tim Springer, a leader in integrin biology, invites aspiring scientists to join his lab to advance groundbreaking research in integrin transmembrane signaling, TGF-β activation, cell surface receptor mechanobiology, and therapeutic development. This role offers mentorship and opportunities to establish a strong scientific foundation for launching an independent research career.

About the Role:

As a Special Postdoctoral Fellow, you will:

• Pursue cutting-edge research in areas such as:
• Novel integrin ligands to drive stem cell and organoid development
• Cryo-EM: Activation of integrins and TGF-β, and ligand binding
• Mechanobiology: Integrin force transduction in rolling adhesion and firm adhesion and TGF-β activation
• Single Molecules: Utilize advanced techniques including FRET and magnetic tweezers to explore conformational change kinetics and force transmission in integrins and selectins
• Innovative ReaLiSM: (Receptor and Ligand in Single Molecules) to study receptor-ligand binding dynamics
• TGF-β Activation: Research localized activation at cell surfaces for new therapeutic targets

• Own and Develop Your Project: We encourage candidates to propose and develop their own research ideas, which they can carry forward to establish their own labs.

Key Techniques and Approaches:

• Single-molecule imaging
• Cryo-EM
• Organoid and stem cell research
• FRET reporters using non-canonical amino acids
• Magnetic and laser tweezers
• Mechanobiology and therapeutic target discovery

Why Join Us?

• Mentorship from Tim Springer, renowned for his pioneering work in integrins and cell biology
• Independence and Growth: Develop projects that will empower your transition to an independent research career
• Collaborative Environment at Harvard Medical School and Boston Children’s Hospital

Application Details: To apply, please email the following to [email protected] with “Special Postdoctoral Fellow” in the subject line:

1. Cover letter (include a brief outline of your project interests)
2. CV
3. Three references

Salary: $78,000 annually

Qualified applicants will receive consideration without regard to race, color, religion, national origin, sex, sexual orientation, gender identity, protected veteran status, or disability.