Sr. Research Associate, Purification and Analytical Chemistry

Circle Pharma is a dynamic biotech company advancing the discovery and development of cell-permeable oral macrocycles. Our platform combines structure-based drug design and advanced synthetic chemistry to create first-in-class macrocycle therapeutics for severe unmet clinical needs. We are focusing our development efforts on cyclins, which are master regulators of the machinery that controls progression of cells through the cell cycle and are key drivers in many cancers.

We seek passionate individuals poised to drive our growth and make a difference. Learn more about Circle Pharma at www.circlepharma.com

We are seeking a Senior Research Associate to join our growing team, reporting to the Senior Analytical Chemist. This role involves performing routine purification and developmental work using preparative liquid chromatography (prep-LC/MS) and analyzing target molecules, including macrocyclic peptides and small molecules, via LC/MS. The individual will also be responsible for the routine maintenance of analytical instruments and liquid handling devices.

The ideal candidate will have experience in purifying macrocyclic peptides and small molecules, as well as strong expertise in liquid chromatography, mass spectrometry, and automated liquid handling systems. A proven track record of productivity and project ownership, along with a solid understanding of small molecule and peptide purification and analysis techniques, is essential.

What You’ll Do:

• Conduct preparative-scale purification and analytical characterization for macrocyclic peptides/ small molecules using preparative LC/MS, UPLC/MS and other instruments
• Conduct large scale of sample preparation on automated liquid handling devices
• Maintain accurate and up-to-date documentation of lab activities; analyze results, generate reports, and communicate results to Chemistry team
• Assist with compound management tasks related to the role
• Draft and revise protocols, methods, and Standard Operating Procedures (SOPs), with guidance
• Order chemicals and consumables for purification and analytical use, conduct lab instrumentation priming/routine maintenance/troubleshooting, coordinate internal/external service for lab instrumentation
• Be an enthusiastic contributor to the efforts of our Analytical/ Purification Team, and aid with activities such as synthesis, compound inventory and dispensing efforts as needed

About You:

• BA degree in Analytical Chemistry, Chemistry, Biochemistry or a related scientific discipline
• 5+ years industry analytical chemistry experience required. More years of experience would qualify you as a Sr. RA.
• Experience in operating and maintaining LC/MS, preparative LC/MS, method development and data analysis required
• Experience with Waters ACQUITY UPLC, Waters QDa Mass Detector, Waters LC Prep AutoPurification System, Waters Empower, MassLynx preferred
• Experience with molecule structure identification by using Mass Spectrometry is a plus
• Experience in organic synthesis and solid-phase peptide chemistry would be a strong plus
• Organized and detail-oriented
• Adept at following written protocols and verbal instructions
• Excellent interpersonal skills and ability to work effectively within a team setting
• Excellent written and verbal communication skills
• Proficiency with Microsoft Office
• Strong interest in understanding the drug discovery process
• Must be able and willing to work at lab bench/fume hood for majority of the workday

Circle Pharma recognizes that the success of our endeavors depends on the success of every team member. Your well-being is our top priority, and we are proud to offer a comprehensive total rewards package. Our benefits include but are not limited to medical, dental, and vision care. We also provide a 401(k) plan with a generous company contribution, and all of our offers contain a stock option component. We provide company-paid life insurance, short-term and long-term disability. Additionally, we provide many company-paid holidays, including a winter break at the close of the calendar year.

Circle Pharma is an equal opportunity employer and committed to a diverse workplace. All applicants will be considered equally without regard to race, color, ethnicity, veteran status, religion, national origin, marital status, political affiliation, age, sex, sexual orientation, gender identity, disability status, membership in an organization or any other non-merit factors.

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