Synthetic nucleic acids for intelligent sensors

In this project we will use organic chemistry to synthesise and evaluate a new class of nucleic acids designed to deliver rapid and simple detection and diagnostic approaches. 

Sensing and detection are crucial aspects of defence and security. Rapid and robust detection of chemical and biological warfare agents is essential for immediate risk assessment, mitigation, and decision-making in the field. Similarly, point-of-care diagnostics enable accurate and rapid disease diagnosis and allow effective therapeutic intervention and epidemiological surveillance; the recent COVID-19 pandemic has highlighted the importance of fast and decentralised testing. Although detection systems based on nucleic acids are among the most sensitive and specific, these assays involve trade-offs between sensitivity, specificity, simplicity, cost, and speed. 

The project will combine state of the art nucleic acid chemistry, photochemistry and electrochemistry with exciting emerging diagnostic CRISPR/Cas technologies. We will start by synthesising and characterising the modified nucleic acids. We will then develop proof-of-principle detection systems using the technology, one focused on detecting biological agents and the other focused on the detection of chemical agents. 

You will gain experience in organic synthesis, nucleic acid chemistry, and senor development.    

For informal enquiries please get in touch with the Dr Ysobel Baker – Y.R.Baker@soton.ac.uk  

Funding for this project is offered by the Centre for Doctoral Training in Complex Integrated Systems for Defence & Security (CISDnS), which will recruit motivated and inquisitive candidates across the themes of Digital, Physical and Biological systems to provide a diverse and interconnected cohort training environment. You can read more about the Centre and the training programme at https://cisdns-cdt.ac.uk/  

To discuss aspect related to the CISDnS CDT please contact the directorate – cisdns@soton.ac.uk  

This PhD studentship is open only to UK applicants. This project is suitable for applicants who hold or expect a 1st class or 2:1 degree in chemistry or a related subject. 

CISDnS is committed to promoting equality, diversity and inclusivity. We welcome all applicants regardless of their gender, ethnicity, disability, sexual orientation or age, and will give full consideration to applicants seeking flexible working patterns and those who have taken a career break or are transitioning into a new role. The University has a generous maternity policy, onsite childcare facilities, and offers a range of benefits to help ensure employees’ well-being and work-life balance. 

Closing date: 5th May 2025

Entry requirements: A very good undergraduate degree (at least a UK 2:1 honours degree, or its international equivalent). Following the diversity objectives of CISDnS, we will accept many forms of equivalent prior learning.

Funding: Full-time studentships will cover UK tuition fees and an enhanced tax-free stipend of approx. £24,700 per year for 4 years, along with a substantial budget for research, travel, and centre activities.  

How to apply

Search for a Postgraduate Programme of Study (soton.ac.uk).  

Select Full-time or Part-time, programme type (Research), 2025/26, Faculty of Engineering and Physical Sciences, next page select “iPhD Complex Integrated Systems in Defence & Security (Full-Time)” 

In Section 2 of the application form you should insert the name of the supervisor Dr Ysobel Baker.

Applications should include:

curriculum vitae giving details of your academic record and stating your research interests

name two current academic referees together with an institutional email addresses in the Reference section of the application form. On submission of your online application your referees will be automatically emailed requesting they send a reference to us directly by email.

your academic transcript and degree certificate (translated if not in English) – if you have completed both a BSc & an MSc, we require both.

include a short statement of your research interests in the Personal Statement section of the application form.