Understanding Autoimmune Diseases Using Mass Spectrometry

Glycans are sugar-based molecules which play an important role in biological processes ranging from cell-cell communication to energy metabolism. The complex interplay between these glycans and cell surface glycan-binding proteins (GBPs) serves a crucial role in immune response modulation. Disruption of these intricate interactions leads to immune dysregulation, which is implicated in conditions ranging from cancer to neurological diseases. One form of immune dysregulation is when the immune system starts to attack healthy cells, a phenomenon referred to as autoimmunity. The biochemical pathways underpinning autoimmunity remain poorly understood, making the resulting medical conditions particularly challenging to diagnose and treat. This project aims to unpick the GBP-glycan interactions which underpin these complicated but fascinating diseases, with a view to improving patient outcomes.

This project will apply a range of chemical biology and biophysical techniques to better understand autoimmune protein-glycan interactions. Particular focus will be on developing the use of biological mass spectrometry to directly measure and characterise these interactions. The student will apply these workflows to a range of biological systems, including purified proteins, cellular models, and human biofluids, to study GBP-glycan interactions across different medically relevant contexts. As such, the student will benefit from training across a variety of techniques and areas, with the project having scope for scientific expansion in line with their own research interests. 

The ideal candidate for this role has a strong interest in biological chemistry and mass spectrometry. Typical experience would be an MChem degree or equivalent in chemistry, biochemistry, or a related scientific subject (or comparable experience). Effective written and verbal communication skills, good time-management and the ability to work in a collaborative environment are essential.