VP, Medical Affairs

Attention recruitment agencies: All agency inquiries are vetted through 4DMT’s internal Talent Acquisition team. No unsolicited resumes will be accepted. Agencies must be expressly engaged by the 4DMT Talent Acquisition team on any requisition. Agencies reaching out directly to hiring managers will not be tolerated and doing so may impact your ability to work with 4DMT in the future.

4DMT is a clinical-stage biotherapeutics company harnessing the power of directed evolution for targeted genetic medicines. We seek to unlock the full potential of gene therapy using our platform, Therapeutic Vector Evolution (TVE), which combines the power of directed evolution with our approximately one billion synthetic AAV capsid-derived sequences to invent evolved vectors for use in our products. We believe key features of our targeted and evolved vectors will help us create targeted product candidates with improved therapeutic profiles. These profiles will allow us to treat a broad range of large market diseases, unlike most current genetic medicines that generally focus on rare or small market diseases. 

We have built a deep portfolio of AVV-based gene therapy product candidates, with five product candidates in clinical trials: 4D-150 for the treatment of wet age-related macular degeneration (wet AMD) and diabetic macular edema (DME), 4D-710 for the treatment of cystic fibrosis lung disease, 4D-310 for the treatment of Fabry disease cardiomyopathy, 4D-125 for the treatment of X-linked retinitis pigmentosa (XLRP), and 4D-110 for the treatment of choroideremia. In addition, we have two product candidates in preclinical studies: 4D-175 for geographic atrophy (GA) and 4D-725 for alpha-1 antitrypsin deficiency.

To-date, we have demonstrated clinical proof-of-concept for three evolved vectors in three therapeutic areas and routes of administration with five products and patient populations. We believe this validates the power of our directed evolution platform for discovering superior vectors compared to wildtype viral vectors. We have built a robust and efficient product engine with 6 open Investigational New Drug Applications (INDs) in the U.S., 1 IND in Taiwan, and 1 Clinical Trial Approval (CTA) in Australia. We believe we are positioned to create, develop, manufacture and, if approved, effectively commercialize targeted genetic medicines that could transform the lives of patients suffering from debilitating diseases.

In addition to TVE, our technology includes a robust AAV manufacturing platform and onsite manufacturing facility that allows us to rapidly produce and test research grade material and scale up to GMP clinical material. This internal capability and close collaboration between our R&D and Manufacturing teams has greatly accelerated the pace of discovery at 4DMT.

Company Differentiators: 

• Fully integrated clinical-phase company with internal manufacturing
• Demonstrated ability to move rapidly from idea to IND
• Five candidate products in the clinic and two declared pre-clinical programs
• Robust technology and IP foundation, including our TVE and manufacturing platforms
• Initial product safety and efficacy data substantiates the value of our platforms
• Opportunities to expand to other indications and modalities within genetic medicine

GENERAL SUMMARY

As a key member of the 4DMT team, this person will provide overall leadership for the Medical Affairs function, overseeing Medical Affairs and supporting business development. The position will inform clinical studies and liaise closely with the physicians responsible for carrying out 4DMT’s clinical studies. This person should be a “leader/doer” capable of generating strategies and leading cross functionally. This VP, Medical Affairs will report directly to the Chief Development Officer.

RESPONSIBILITIES:

Lead the Medical Affairs function at 4DMT

• Develop and implement key Medical Affairs strategies and activities to support the development of our lead assets
• Develop and present Medical Affairs operational plans to Development and Executive management
• Represent company externally
• Direct and oversee all aspects of Medical Affairs and pre-launch needs
• As a member of the Development Leadership Team, run and continue to build the Medical Affairs function
• Build and lead a best-in-class global medical affairs team to support launches of 4D-150 and other development candidates multiple indications including, but not limited to, nAMD and diabetic eye disease.
• Develop key performance indicators and generate analytical reports related to Medical Affairs plans and External Liaison group activities
• Develop and implement Medical Communication and Disease State Awareness strategies
• Partner with KOLs to gather information on current focused therapeutic area issues and questions
• Collaborate with the Commercial team to develop educational material for providers and patients that are balanced and medically accurate
• Provide direction and input into the development and implementation of successful reimbursement and market-access strategies
• Work closely with the members of the clinical development and commercial leadership teams to develop the overall strategic direction for 4DMT, evaluate alternative strategies, identify competitive issues, and develop and implement operating plans to achieve company objectives
• Foster collaborative relationships with academic and clinical experts, publishers, medical and patient associations, and other relevant external and internal stakeholders
• Develop and manage departmental budgets that effectively achieve desired goals that are balanced with the financial objectives of the broader organization Other duties as assigned, nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time

QUALIFICATIONS: 

Education nearmejobs.eu Experience nearmejobs.eu Skill Requirements

• Advance degree (MD, PhD, or PharmD)
• 10+ years of professional experience within Biotech/Pharma in Medical Affairs
• 5+ years of people leadership experience
• An understanding of government and industry guidelines, regulations, laws, etc., for appropriate scientific/medical exchange and communication with customers
• Ability to lead by example, attract and develop talent, build interdependent partnerships, and create a culture of collaboration and teamwork that fosters open communication, constructive conflict resolution and organizational flexibility
• Ability to prioritize and manage several complex projects simultaneously
• Proven ability to develop internal relationships in a highly matrixed environment, as well as external relationships with Key Opinion Leaders and industry experts
• Ability to communicate effectively at all levels and present complex and/or new ideas with clarity and simplicity
• Ability to prioritize concurrent projects with tight deadlines and operate in a highly compliance-driven environment
• Excellent written, verbal, and interpersonal skills, and the ability to communicate at all levels within the company
• Travel (25-40%) may be required to represent the company at medical conferences, presentations, and other meetings

Base salary compensation range: $336,000 – $394,000

Please note, the base salary compensation range and actual salary offered to the final candidate depends on various factors: candidate’s geographical location, relevant work experience, skills, and years of experience. 

4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws.

Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

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