What is the role of steroid hormones made in the brain?

Project Overview: 

Many behaviours differ between the sexes and this is often controlled by hormones. In our laboratory, we explore how hormones regulate behaviours that differ between the sexes. Though these hormones are typically made by the gonads and adrenals, we are especially interested if they are made in the brain and if this is important for social behaviour and to healthy aging.  Hence, this project is designed to understand how locally brain-produced steroid hormones are relevant for neuronal health and behaviour, using mice as a model. We will investigate the regulation of neurosteroid synthesis in the brain by both internal and external chemicals. Using brain slices, animals and cell lines, we will also explore the signalling by these locally produced estrogens in the brain, including signalling via well-characterized intracellular nuclear receptors and novel membrane receptors. Depending on the interest of the student, this project can be focused on molecular signalling by hormones and/or behavioural analyses or on stress and aging. If successful, this project will highlight the role of locally produced steroids and uniquely show evidence that they may signal as neurotransmitters in the mammalian brain.  In addition, this can help us understand side-effects of aromatase inhibitors that are used in cancer therapy to decrease oestrogen levels in the body and for neuroprotection against neurodegeneration.

The student will be part of a vibrant neuroendocrine group with an opportunity to network with overseas collaborators. Dr Vasudevan supervises or co-supervises 8 students in interdisciplinary projects ranging from oscillations in biology, autism and regulation of behaviour. The student will learn several experimental techniques including immunoassays, molecular biological techniques, slice culture, cell culture, manipulation of genetically modified mouse models, cell biology assays and behavioural analysis. For students interested in mentoring, there are opportunities to serve as co-advisors in summer or autumn undergraduate projects.

University of Reading:

The University of Reading, located west of London, England, is ranked at 172 globally, according to the QS World University Rankings 2025. 98% of research at the University is of international standing (REF 2021, combining the University’s world leading, internationally excellent and internationally recognised submissions). The University’s main Whiteknights Campus is set in 130 hectares of beautiful, award-winning parkland, less than a 30-minute train ride to London Paddington and is approximately 30 miles from London Heathrow airport. 

Our School of Biological Sciences conducts high-impact research, tackling current global challenges faced by society and the planet. Our research ranges from understanding and improving human health and combating disease, through to understanding evolutionary processes and uncovering new ways to protect the natural world. In 2020, we moved into a stunning new ~£60 million Health & Life Sciences building. This state-of-the-art facility is purpose-built for science research and teaching. It houses the Cole Museum of Zoology, a café and social spaces.

In the School of Biological Sciences, you will be joining a vibrant community of ~180 PhD students representing ~40 nationalities. Our students publish in high-impact journals, present at international conferences, and organise a range of exciting outreach and public engagement activities.

During your PhD at the University of Reading, you will expand your research knowledge and skills, receiving supervision in one-to-one and small group sessions. You will have access to cutting-edge technology and learn the latest research techniques. We also provide dedicated training in important transferable skills that will support your career aspirations. If English is not your first language, the University’s excellent International Study and Language Institute will help you develop your academic English skills.

The University of Reading is a welcoming community for people of all faiths and cultures. We are committed to a healthy work-life balance and will work to ensure that you are supported personally and academically.

Eligibility:

·        Applicants should have a good bachelor’s degree (minimum of a UK Upper Second (2:1) or equivalent)/master’s degree in Biology or a strongly-related discipline. Molecular Biological or behavioural experience in any system a plus, but not necessary.

·        International applicants will also need to meet the University’s English Language requirements. We offer pre-sessional English courses that can help with meeting these requirements.

The University of Reading is committed to a policy of equal opportunities and non-discriminatory treatment for all members of its community.

How to apply:

Submit an application for a PhD in Biomedical Sciences  via our online application system.

 

Further information:

Please visit the School of Biological Sciences PhD webpage

 

 

Enquiries:

Dr. Nandini Vasudevan, email: n.vasudevan@reading.ac.uk