This project will be mainly supported by a newly funded NIH R01 with Dr. Matthew Greenblatt of Weill Cornell Medicine and Dr. Xu Yang of the Arthroplasty Research Lab at the Hospital for Special Surgery as Co-PIs. We will develop key initial elements of a new approach for the regeneration of amputated limbs, by transducing a specific population of autologous skeletal stem cells to induce a blastema-like state, and then implanting them into the amputation site to initiate regeneration of the missing limb.
The candidate may also participate in other projects to invest the cellular and molecular mechanism of the implant osseointegration, including an on-going project funded by Department of Defense.
A candidate having a recent Ph.D. degree in Developmental Biology, Cell and Molecular Biology, or Neuroscience will be desirable. Writing skill and expertise in mouse genetics, light and confocal microscopy, and gold-stand techniques of cell and molecular biology are required. The candidate is expected to have one or more high quality first author publications on cell biology or mouse models of disease or both. The candidate should be highly motivated and productive and interested in a career in research. Expertise in mouse models for wound healing and/or in working with skeletal stem/progenitor lineage cells would be a plus.
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